Separation from the world is essential to Christian holiness. Yet true separation-holiness is defined by the the Holy One. Separation that does not flow from the Spirit of God through the Scriptures is not separation from the world at all. It is worldly separation, separation defined by religious tradition. And religious tradition is the worst sort of worldliness in the world.
The call to “come out from among her and be separate” is a call to come out of manmade-religion, whether pagan idolatry, Judaistic legalism or modern Christian tradition. Are you willing to be separate from the world? Then you must start by being willing to be separate from your religion.
Are you willing to come out and follow Jesus?